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O. Palumbo

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Review Open access Aug 2026

Phenotype‐guided etiologic workup in a prospective cohort of 144 adults with developmental and epileptic encephalopathy

The practical value of this approach lies not only in diagnostic yield, but in showing that structured adult reassessment remains clinically worthwhile, shows that adults with suspected DEE can still benefit from careful diagnostic reassessment, even years after childhood.

G. d'Orsi, Umberto Costantino, M. T. Di Claudio et al. · 1 citation
Open access Jul 2026

Mutant Huntingtin disrupts neurogenic and astroglial programs via the EZH2-Let-7g-LIN28 axis with rescue by epigenetic modulators.

It is shown that neurogenesis is disrupted at multiple stages of lineage progression in both rodent and human neural stem cell models of Huntington's disease, and a panel of clinically relevant epigenetic compounds hold promise for stage-spanning therapeutic strategies capable of modifying disease trajectory.

Jessica Rosati, A. Casamassa, G. Ruotolo et al. · 0 citations

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