Open access
Oct 2026
Methylation profiling reveals epigenetic programs associated with chr18 loss in small intestinal neuroendocrine tumors
Small intestinal neuroendocrine tumors (SI-NETs) are characterized by a low mutational burden and limited recurrent driver mutations, suggesting that other mechanisms contribute to tumor development. One of the most frequent genomic alterations in SI-NETs is loss of heterozygosity on chromosome 18 (chr18del), which...
F. Axling, S. Backman, Per Hellman et al.
· Frontiers in Oncology · 0 citations