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Ischemic stroke and subsequent reperfusion injury are major causes of mortality and long-term neurological disability, driven by complex mechanisms of excitotoxicity, oxidative stress, neuroinflammation, endothelial dysfunction, and blood-brain barrier disruption. Increasing evidence indicates that long non-coding RNA...
This study proposes and evaluates a novel solar–biomass hybrid multigeneration system from thermodynamic, exergoeconomic, and environmental perspectives. The integrated configuration consists of an intercooled gas turbine cycle, a photovoltaic thermal-assisted polymer electrolyte membrane (PEM) electrolyzer for hydro...
Breast cancer remains a significant clinical challenge, particularly in triple‑negative breast cancer (TNBC), in which therapeutic resistance limits treatment efficacy. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising strategy to overcome resistance in...
A polymer engineering perspective provides a more mechanistically useful basis for dECM bioink design than biological fidelity alone, and matching tissue-specific matrix composition, crosslinking architecture, rheological behavior, and printing parameters is essential for advancing dECM-based constructs toward clinical...
The global resistome is mapped to map the global resistome, quantify temporal and host-specific trends, and assess the association between genetic determinants and phenotypic resistance by analyzing over 110,000 S. aureus genomes.
Clinical translation remains limited by dependence on retrospective transcriptomic datasets, insufficient mechanistic validation, lack of standardized assays, and scarce prospective clinical evidence, but pyroptosis-associated lncRNAs represent a promising link between tumor progression and immune regulation, with cons...
Challenges such as scalable production, cargo heterogeneity, and regulatory considerations remain, but ongoing advances in exosome engineering and patient-derived vesicles are poised to overcome these barriers.
A comprehensive analysis of ML-driven methodologies for denoising, spectral decomposition, feature extraction, and high-accuracy classification in CQD fluorescence systems shows how ML enables ultra-low-level analyte detection, interpretable photophysical modeling, and real-time intelligent sensing across chemical and...
SIRT1–GAPDH signaling represents a post-translational axis linking sirtuin activity directly to glycolytic enzyme function, distinct from SIRT1's traditional transcriptional roles and serving as a viable molecular checkpoint in microglial immunometabolism.
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