SIRT1 deacetylates GAPDH to drive microglial glycolysis and neuroinflammation
SIRT1–GAPDH signaling represents a post-translational axis linking sirtuin activity directly to glycolytic enzyme function, distinct from SIRT1's traditional transcriptional roles and serving as a viable molecular checkpoint in microglial immunometabolism.
Chou-Yi Hsu, Ibrokhim B. Sapaev, O. Nematov et al.
· Frontiers in Immunology · 0 citations