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Author

O. F. Karatas

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2 papers indexed here

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Sep 2026

Obesity associated elevated leptin might contribute to paclitaxel resistance via PLCB1/IP3R1 axis in head and neck cancers.

BACKGROUND Head and neck cancer (HNC) is a heterogeneous malignancy with limited therapeutic success, largely due to its complex pathogenesis and high chemoresistance. Paclitaxel is commonly used in HNC therapy; however, the frequent development of resistance reduces its efficacy. Obesity has been linked to cancer prog...

Fatma Şanli, Betul Gundogdu, O. F. Karatas · 0 citations
Open access Oct 2026

Synthesis, Anticancer Evaluation, and Theoretical Investigation of Novel Guanidine‐Based Imidazole Derivatives

Fifteen new guanidine‐based imidazole ring‐containing compounds were synthesized and their structures were characterized by 1 H NMR, 13 C NMR, mass spectroscopy, and x‐rays methods. The anticancer activity of the new derivatives was tested against hypopharyngeal cancer cells. Among all the compounds, compound...

Rıfat Emin Bora, Eylül Doğan, Neslişah Barlak et al. · 0 citations

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