Author

O. Erfan

2 papers indexed here

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Oct 2026

Hesperidin attenuates methotrexate-induced cardiotoxicity: Modulation of Nrf2 antioxidant defense and NF-κB/iNOS proinflammatory signaling.

Methotrexate (MTX) is a commonly used chemotherapeutic and immunosuppressive agent, although serious adverse effects, including cardiotoxicity, sometimes compromise its clinical use and effectiveness. This work was designed to investigate the mechanisms underlying MTX-induced cardiac injury and to evaluate the potentia...

M. Eldesoqui, E. Albadawi, O. Erfan et al. · Tissue & Cell · 0 citations

Sep 2026

Empagliflozin shields brain from methotrexate toxicity: Nrf2/HO-1/GPX4 activation prevents ferroptosis and chemo-brain in rats.

BACKGROUND Methotrexate (MTX) can induce "chemo-brain," but mechanisms remain incompletely defined. Ferroptosis has been implicated in MTX toxicity. We investigated whether Empagliflozin (EMPA) protects against MTX-induced neurotoxicity by modulating ferroptosis-related pathways. METHODS Male Sprague-Dawley rats (n =...

Mohammad El-Nablaway, Hend M. Hassan, O. Erfan et al. · Tissue & Cell · 0 citations