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Author

O. Delattre

2 papers indexed here

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Sep 2026

Abstract PR006: Activated ALK and MYCN drive neuroblastoma initiation through tissue-specific dynamics of neuroblast persistence and transformation

Neuroblastoma (NB) is an embryonal malignancy of the sympathetic nervous system that arises in either the adrenal gland or sympathetic ganglia. However, its developmental origin and the earliest steps of tumor initiation remain incompletely understood. We investigated how ALK activating mutations and MYCN overexp...

Nour El Houda Djerir, Amira Kramdi, Cécile Thirant et al. · 0 citations
Aug 2026

DNMT3B plays antagonistic roles with SMARCB1 and is a targetable vulnerability in rhabdoid tumors.

PURPOSE Rhabdoid tumors (RTs) are highly aggressive pediatric cancers driven by the biallelic inactivation of the SMARCB1 tumor suppressor gene, the sole recurrent genetic alteration. SMARCB1 encodes a core subunit of the SWI/SNF chromatin remodeling complex; its loss disrupts epigenetic gene regulation, supporting the...

C. Chauvin, Ryszard Wimmer, Ludovica Brunetti et al. · 0 citations

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