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O. Bobiļeva

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Open access Sep 2026

Characterization of the N7 RNA cap methyltransferase from Trichomonas vaginalis and inhibitor discovery

RNA cap formation is essential for eukaryotic gene expression, yet the enzymes responsible for cap methylation remain poorly characterized in many eukaryotic parasites, including Trichomonas vaginalis. Here, we functionally and structurally characterized the RNA guanine-N7 methyltransferases (MTases) from T. vaginalis,...

J. Benýšek, D. Chalupska, Milan Štefek et al. · 0 citations
Open access Aug 2026

Adenosine 5′-Carboxamide-Based Inhibitors of METTL1

METTL1 is the human RNA methyltransferase that catalyzes the methylation of N7-guanosine in RNA. Overexpression of METTL1 has been linked to cancer, and increasing evidence supports the therapeutic potential of METTL1 inhibition in oncology. In this study, we have optimized a series of adenosine 5′-carboxamide derivati...

O. Bobiļeva, Francesco Nai, Sandija Niedrite et al. · 0 citations

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