Pharmacokinetic and pharmacodynamic profile of high-dose D9-tetrahydrocannabinol in male and female rats.
Cannabis products with elevated Δ9-tetrahydrocannabinol (THC) content are prevalent in parts of North America, yet their pharmacokinetic (PK) and pharmacodynamic (PD) properties remain incompletely characterized. We investigated the effects of a single administration of high-dose THC (10 and 30 mg/kg, intraperitoneal,...