Nurdan Kuru

PHACTn enables training-free, context-independent inference of nucleotide variant tolerance across the genome

PHACTn (Phylogeny-Aware Computing of Tolerance for nucleotide variants), a training-free, parameter-minimal method that infers nucleotide variant tolerability by traversing the mammalian phylogenetic tree and explicitly modeling the evolutionary independence of observed substitutions and their distance from the query s...