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Nur Hani Hani Zainal

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Open access Sep 2026

Prospective associations of cortisol dynamics and daily stress with depression, generalized anxiety, and panic disorder symptoms.

BACKGROUND Flatter diurnal cortisol decline indicates hypothalamic-pituitary-adrenal (HPA) axis dysregulation and has been longitudinally related to major depressive disorder (MDD), generalized anxiety disorder (GAD), and panic disorder (PD) symptoms. However, given high heterogeneity in the relationship between diurna...

Nur Hani Hani Zainal, Natalia Van Doren · 0 citations
Open access Aug 2026

Baseline prediction of two-year prevention and remission of anxiety, depression, and eating disorders in college students receiving a digital guided self-help intervention: derivation and external validation of a machine learning algorithm across 26 population-based cohorts.

INTRODUCTION We examined whether machine learning identified baseline variables that predicted two-year prevention and remission from anxiety, depression, and eating disorders following digital cognitive-behavioral therapy guided self-help (D-CBTgsh). METHODS Undergraduates at risk for or meeting criteria for anxiety...

Adam Calderon, Dao-Yi Zhu, Nur Hani Hani Zainal et al. · 0 citations
Open access Aug 2026

Predicting six-year depression trajectories in adulthood: A super learner ensemble approach using the Add Health dataset.

BACKGROUND Depression is a leading global cause of disability, and much focus has been directed toward identifying population-wide predictors of adult depression. The present study aimed to identify the strongest predictors of future depression severity using a comprehensive panel of biopsychosocial predictors and the...

Jordan W J Chng, Kean J. Hsu, Nur Hani Hani Zainal · 0 citations
Open access Aug 2026

Sleep fragmentation and heightened inflammation: A latent profile subtype predicting nine-year major depressive disorder severity in the MIDUS study

A neuroimmune profile characterized by proinflammatory activity and insufficient, fragmented sleep functioned as a distal risk factor of MDD symptoms and a person-centered, multimodal risk stratification approach may enhance targeted prevention of long-term MDD.

Nur Hani Hani Zainal, S. Beaudreau · 0 citations
Open access Aug 2026

Blunted Diurnal Cortisol Slope as a Risk Marker for 9-Year Executive Function Decline: Amplification by Daily Stress and Worry Severity.

OBJECTIVES Cortisol dysregulation, reflective of hypothalamic-pituitary-adrenal (HPA) axis dysregulation, has been linked to executive functioning (EF) decline. However, substantial effect-size heterogeneity across studies highlights the potential role of psychosocial moderators. We investigated whether the severity of...

Nur Hani Hani Zainal, Stephanie Noble · 0 citations
Open access Aug 2026

From allostasis to addiction: Cortisol dysregulation, daily stress and relations with 9-year alcohol and substance use disorder severity in community adults.

Nonlinear interactions between cortisol indices and daily stressor severity appear to predict 9-year alcohol use disorder and substance use disorder severity, with cortisol area under the curve emerging as the most robust indicator.

Nur Hani Hani Zainal, Natalia Van Doren · 0 citations

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