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Author

Nuo Chen

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Preprint Aug 2026

Benchmarking Clinical Decision Pathway Adherence in Large Language Models

Experiments on 16 representative LLMs show that reliable clinical decision support remains challenging for current models, demonstrating the need for CDP-oriented evaluation and the value of MEGA-CDP for advancing guideline adherence in medical LLMs.

Nuo Chen, Xin Jiang, Zi-Long Wang et al. · 0 citations
Jul 2026

Designing Fidelity of CRISPR-Cas Endonucleases by Kinetic Insights

A PLM-assisted physics-driven approach is presented that utilizes atomistic molecular dynamics simulations and automated path searching to efficiently obtain the complete kinetic insights, including the transition state structures, for the conformational changes of Cas before DNA cleavage.

Huihui Liu, Zhenyu Zhou, Luowei Yuan et al. · 0 citations

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