Author

Nuno Vale

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#protein folding Open access Oct 2026

Integrating PBPK Simulation and In Vitro Pharmacodynamics to Model Efavirenz-Associated Hepatic Oxidative Stress in Pregnancy

Background: Certain antiretroviral drugs, including efavirenz, have been associated with mitochondrial and oxidative effects in hepatic cells, but quantitative translation from nominal in vitro concentrations to an in vivo effect-site concentration remains uncertain. Methods: A hypothesis-generating physiologically bas...

Bárbara Costa, M. Gouveia, Nuno Vale · Pharmaceutics · 0 citations

Open access Sep 2026

Pharmacokinetic Variability of Direct Oral Anticoagulants and Calcium Channel Blockers: A Comparative Analysis of Exposure Data from Clinical Studies

Background/Objectives: Interindividual pharmacokinetic (PK) variability remains a daunting challenge for effective and safe drug therapy. Despite the widespread use of direct oral anticoagulants (DOACs) and calcium channel blockers (CCBs), a substantial number of adverse drug reactions have been reported for both class...

Lara Marques, Nuno Vale · Pharmaceutics · 0 citations