Open access
Jul 2026
A cryptic aromatic binding pocket in the highly thermostable GpgS from Mycobacterium hassiacum hints at MGLP pathway crosstalk
The findings establish M. hassiacum as a valuable model for structural enzymology in mycobacteria and highlight GpgS as a potential drug target, opening new avenues for the development of inhibitors targeting this key, potentially pleiotropic enzyme.
Daniela Nunes-Costa, Alexandra Silva, Susana Alarico et al.
· Protein Science · 0 citations