Open access
Sep 2026
Gefitinib-based therapy in refractory hepatocellular carcinoma with EGFR overexpression: a spatial profiling-guided case report
A case of a patient with advanced HCC who developed cutaneous, pulmonary, and lymphatic metastases following failure of multiple lines of tyrosine kinase inhibitors including donafenib and regorafenib is presented, highlighting the potential benefit of an EGFR-targeted triplet strategy in refractory HCC with EGFR prote...
Qin Xu, Xiao-Fen Li, Rui Zhu et al.
· Frontiers in Immunology · 0 citations