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Nozomu Yachie

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Open access Sep 2026

Global tree encoding of atlas-scale single-cell genomics

MILK is presented, a scalable computational framework that organizes high-dimensional single-cell populations into unified tree representations that establish the hierarchical organization of biological data as a scalable and unifying representation of cellular identity, enabling integrative analysis of single-cell gen...

Brett Kiyota, Chaehyeon Lee, Hao-Yang Yao et al. · 0 citations
Open access Sep 2026

The Gp78 ubiquitin E3 ligase drives mitophagy by regulating omegasome formation

Autophagy is initiated at endoplasmic reticulum (ER)-associated omegasomes, yet how the ER contributes to mitochondrial cargo degradation during early autophagosome formation remains unclear. Gp78 is an ER-resident RING E3 ubiquitin ligase involved in ER-associated degradation (ERAD) that also promotes Parkin-independe...

Milene Ortiz-Silva, Bharat Joshi, Jerry Zheng et al. · 0 citations
Open access Aug 2026

A cuffed CRISPR guide RNA for microRNA activity-dependent genome editing

Cells in multicellular eukaryotic systems are diverse biological units, with characteristics and functions determined by their molecular profiles. CRISPR–Cas9 genome editing has been widely used across biology to modulate gene expression and study gene function. However, there is currently no versatile and scalable met...

Arman Adel, Yuta Shuto, Shunsuke Kawasaki et al. · 0 citations

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