Review
Sep 2026
Mutant isocitrate dehydrogenase in cancer: Structural biology, small-molecule inhibitors, and future drug discovery strategies.
This review classifies mutant IDH inhibitors by chemical scaffold and relates their binding in the allosteric pocket to structure-activity trends, isoform selectivity, brain penetration, and clinical outcome.
Moataz A. Shaldam, Anwar A. El-Hamaky, Nourhan A. Khattab et al.
· Drug Discovery Today · 0 citations