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Norhan Hassan

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Open access Aug 2026

Compact type II-C Cas9 nucleases with expanded PAM access and high fidelity for therapeutic genome editing

Three previously uncharacterized compact type II-C Cas9 orthologs are identified, and all show a strong deletion-biased repair signature and no detectable editing across 33 predicted off-target sites, expanding the CRISPR targeting space for AAV-deliverable therapeutic editing.

Qiaochu Wang, Sivakrishna Rao Gundra, Rashid Aman et al. · 0 citations

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