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Author

Nobue Takaiso

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Review Open access Sep 2026

Interpreting TP53 pathogenic variants in germline testing and cancer genomics: pathogenicity, origin, and clinical actionability.

An origin-aware, three-layer framework comprising variant pathogenicity assessment, origin attribution, and clinical actionability is proposed to support proportionate surveillance, cascade testing, and shared decision-making.

I. Imoto, Nobue Takaiso, A. Yoshimura · 0 citations

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