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Dendritic morphology constrains microtubule dynamics and organization
Neuronal dendrites form highly branched morphologies supported by spatially patterned microtubule arrays that are essential for intracellular transport and structural stability, yet how this organization is established and maintained remains unclear. Here we analyze microtubule behavior in Drosophila sensory neurons us...
Identifying and reprogramming softness-driven cancer stem-like cells overcomes CAR-T cell resistance in solid tumours.
To render these resistant cells targetable, the mechano-recorder is rewired into a mechano-reprogrammer by replacing the fluorescent output with the clinically validated antigen CD19, enabling softness-responsive cells to be recognized by CD19-directed T cells.