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Review Sep 2026

Drug resistance in cancer: Emerging mechanisms, translational barriers, and pharmacological strategies.

Multidrug resistance (MDR) remains a major challenge in cancer treatment. MDR has been explained by single-gene mechanisms, such as overexpression of ATP-binding cassette (ABC) transporters, drug-target mutations, activation of bypass signaling pathways, and increased DNA repair. However, these mechanisms alone are ins...

Xiang Chen, Qin-Guo Huang, Ryan Li et al. · 0 citations

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