Author

Ning Ma

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Open access Sep 2026

A small molecule ACT004 targets four-and-a-half LIM domain protein 1 to disrupt TGF-β/Smad signaling and promote FHL1 degradation in renal fibrosis.

Renal fibrosis is a common endpoint of chronic kidney disease (CKD), yet effective targeted anti-fibrotic therapies remain limited. Ovatodiolide (OVA) has anti-fibrotic activity but poor drug-like properties, whereas ACT004, a synthetic OVA derivative, has improved water solubility and metabolic stability. However, whe...

Xiao-Yang He, Fen-Fen Peng, Hui-Zhen Wang et al. · Pharmacological Research · 0 citations

Aug 2026

The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing β-catenin signaling.

The expression of the circRNA circKLHL20_009 was significantly upregulated in the myocardium of patients with heart failure and in human cardiomyocytes treated with angiotensin II and an artificial circRNA sponge, circSPmiR31, effectively mitigated cardiac hypertrophy and fibrosis by suppressing miR-31-5p binding to Dk...

Yi-hong Wen, Jia-xue Jiang, W. Dong et al. · Acta Pharmacologica Sinica · 0 citations