Author

Ning-Jing Lei

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Open access Oct 2026

Machine learning and multi-omics analyses reveal CLDN1 as a candidate marker associated with colorectal cancer invasion and nutlin-3a (-) response.

OBJECTIVE Colorectal cancer (CRC) is molecularly, cellularly and spatially heterogeneous, and current staging systems and biomarkers incompletely explain prognosis and treatment response. This study integrated transcriptomics, machine learning, single-cell RNA sequencing, spatial transcriptomics and in vitro experiment...

Wenqi Shan, Qian-Yu Li, Wei Yuan et al. · Translational Oncology · 0 citations

Open access Sep 2026

Tumor-associated osteoclasts converge on a matrix-sulfation program across human bone tumors

Introduction Osteoclasts mediate the bone destruction that drives much of the morbidity of giant-cell tumor of bone, osteosarcoma, and skeletal metastasis, yet these large multinucleated cells are lost in droplet single-cell data and have never been defined as a disease cell state. Methods We reanalyzed 378,936 cells f...

Meng-Yuan Lei, Shu-Ya Chang, Ning-Jing Lei et al. · Frontiers in Cell and Develo... · 0 citations

Open access Aug 2026

Reprogramming pulmonary B cells by ANXA1 silencing halts lung metastatic niche formation in breast cancer

Lung metastasis remains a determinant of poor prognosis and survival in breast cancer and is understood to depend on a permissive pulmonary immune niche rather than tumor cell traits alone. Here, we developed a host-directed RNA interference strategy to modulate this niche by reprogramming pulmonary B cells for breast...

Xiao-Bo Gao, Meng Zhang, Xiao-Han Yao et al. · Journal of Nanobiotechnology · 0 citations