Review
Open access
Sep 2026
Immunometabolic programming of macrophages and tumor-associated macrophages: metabolic pathways shaping polarization, immune regulation, and disease outcomes
This review integrates core macrophage immunometabolic pathways with TAM biology, emphasizing how lactate accumulation, altered lipid mediators, cholesterol remodeling, and amino acid dependencies reshape macrophage states and suppress antitumor immunity through checkpoint signaling and metabolic deprivation.
Jia-Wei He, Bo-Wen Wang, En-Ze Lei et al.
· Frontiers in Immunology · 0 citations