Oct 2026
H3K4me1-Mediated Epigenomic Priming of Chemoresistant Tumor States in Ovarian Cancer.
Non-genetic intratumor heterogeneity underlies therapeutic failure in cancer, yet how resistant tumor states are encoded in patients remains unclear. In this study, we show that chemoresistant evolution in high-grade serous ovarian cancer (HGSOC) is prefigured by epigenetically primed tumor cell states present before t...
Y. Landais, J. Bertorello, M. Puerto et al.
· Cancer Discovery · 0 citations