Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo.
An in vitro system that generates inducible yolk sac myeloid progenitors (iYSMPs) to model human myeloid ontogeny and define a human yolk sac progenitor state with broad TRM differentiation potential, opening avenues for investigating human myeloid ontogeny and developing macrophage cell replacement therapies to treat...