Author

Nick Powell

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Open access Aug 2026

A microbiota-responsive polyfunctional cytotoxic CD4⁺ T-cell state promotes mucosal inflammation in ulcerative colitis

Ulcerative colitis (UC) is characterised by chronic colonic inflammation with marked heterogeneity in disease severity and therapeutic outcomes. Here, we define a spatially organised, polyfunctional cytotoxic CD4⁺ T-cell state associated with mucosal inflammation and adverse therapeutic outcomes in UC. Integrating ex v...

John P Thomas, S. H. Kottoor, Jonathan W. Lo et al. · bioRxiv · 0 citations

Review Open access Aug 2026

The gut microbiome organ

This review synthesizes current mechanistic and translational evidence to conceptualize the gut microbiome as an organ‐like functional system, delineate its structural and functional organization, and propose a framework for mapping, modeling, and therapeutically targeting microbiome‐derived circuits to support precisi...

Yang Bi, Wei-Bin Song, Maria Glymenaki et al. · iMeta · 0 citations