Author

Nicholas T. Crump

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Open access Sep 2026

CXXC1-dependent IRF4 activity promotes myeloma cell fitness and sustains lenalidomide resistance.

Regulation of oncogenic transcriptional programs in multiple myeloma requires the interplay of histone modifications, their writers and readers with lineage-affiliated transcription factors. The transcription factors IKZF1/3, IRF4 and MYC form an aberrant, myeloma-specific regulatory loop that drives myelomagenesis and...

P. Sabbattini, Nikolaos Trasanidis, J. Taslim et al. · Blood · 0 citations

Open access Aug 2026

mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-cell precursor acute lymphoblastic leukemia.

It is demonstrated that overexpression of wild-type IKZF1, a tumor suppressor frequently mutated in high-risk BCP-ALL, upregulates CD20 and promotes leukemic B cell maturation, and the use of mTORC1 inhibitors to sensitize BCP-ALL cells to CD20-directed immunotherapies is supported.

Agnieszka Dąbkowska, Martyna Janowska, Agata Pastorczak et al. · Leukemia · 0 citations