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Nicholas Donohue

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Open access Aug 2026

Modified Plasmids and Inverted Terminal Repeats Enhance Adeno-Associated Virus Production and Performance

A 140% increase in pHelper plasmid production is reported, while the most successful ITR variant increased pTransgene plasmid yields by 57% and transgene expression by 28%, without reducing rAAV yields or transduction efficiency.

Nicholas Donohue, Alexandra Bogdanovic, James Conheady et al. · 0 citations

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