Nicha Ungvijanpunya

PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

Spliceosomopathies, which are a group of disorders caused by defects in the splicing machinery, frequently affect the craniofacial skeleton and limb, but the molecular mechanism underlying this tissue-specific sensitivity remains unclear. Splicing factors and small nuclear ribonucleoproteins (snRNPs) are core component...