Author

Nevenka Dimitrova

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Review Open access Oct 2026

Beyond Segmentation Accuracy: Evaluating Biological Fidelity in Spatial Pathology

It is argued that cell segmentation for spatial pathology should be evaluated not only by boundary and instance accuracy, but also by preservation of the biological relationships that downstream analyses are intended to measure.

Nevenka Dimitrova, Marjan Stoimchev, A. Filliol et al. · bioRxiv · 0 citations

Open access Oct 2026

Discovering Latent Scientific Concepts through Discrete Representation Learning

Scientific imaging is undergoing a fundamental transformation. Advances in multiplex immunofluorescence, computational pathology, and electron microscopy now enable observation of biological and physical systems at unprecedented spatial resolution. Rather than simply classifying known objects, these data offer the oppo...

Marjan Stoimchev, Monu Verma, A. Filliol et al. · bioRxiv · 0 citations

Open access Aug 2026

Single-Cell Profiling of Apoptotic Resistance in Patient-Derived Xenografts and Primary Circulating Tumor Cells Using TetherChip.

Circulating tumor cells (CTCs) must escape the primary tumor and spread to distant organs through harsh, nonadherent blood, and lymphatic microenvironments, where over 99% perish. Some CTCs survive by resisting extracellular matrix (ECM) detachment-induced apoptosis (anoikis). CTC enumeration has already been directly...

Darin E. Gilchrist, Keyata N. Thompson, Julia A. Ju et al. · ACS Applied Materials and In... · 0 citations