Jul 2026
Identification of novel pyrazolines and isoxazolines as antileishmanial agents via a potential antifolate mechanism: synthesis, biological evaluation, and in silico studies.
Based on its superior potency, high selectivity, and stable target binding in silico, the S-enantiomer of compound 1g represents a promising lead for further antileishmanial development.
Menna Desouky, Menna S. Hany, Ahmed R Elaraby et al.
· Bioorganic chemistry (Print) · 0 citations