Silymarin loaded hyaluronic acid-coated cubosomal gel for topical delivery: Optimization, characterizations, and ex vivo skin permeation studies.
OBJECTIVE This study aimed to develop a silymarin (SLM) loaded cubosomal gel and coat it with hyaluronic acid on the surface of the optimized formulation to evaluate skin permeation efficiency. METHODS The cubosomes (CBS) was prepared using a top-down method with monoolein, poloxamer 407, and sonication. A Box-Behnke...