Hypoxia is a defining feature of the solid tumor microenvironment and a central driver of cancer-stem-cell (CSC) biology, yet the epigenetic mechanisms linking oxygen deprivation to stemness, metastasis, and therapy resistance remain fragmented across the literature. This review synthesizes that evidence into a unified...
M. Al-khreisat, Rustam Narzikulov, O. Allela et al.· Gene· 0 citations
Mutation-based liquid biopsy supports diagnosis and disease monitoring in hematologic malignancies, but interpretation of plasma variants may be complicated by clonal hematopoiesis, treatment-related changes, and nonmalignant blood-cell turnover. This structured narrative review evaluates whether cell-free DNA (cfDNA)...
Amr A. El-Sehrawy, Sarmad S. Abdullah, Guzalya Mamedova et al.· Translational Oncology· 0 citations
The gut microbiome has emerged as a potential contributor to cardiovascular diseases (CVDs), including atherosclerosis, acute coronary syndrome (ACS), and peripheral arterial disease (PAD). While observational studies link dysbiosis to CVD, causal relationships remain uncertain.
Amr A. El-Sehrawy, Usamah Sayed, Z. Nasirova et al.· Clinical Cardiology· 0 citations
Sepsis is a critical medical state considered a life-threatening response to infection, leading to extensive inflammation and potential organ dysfunction. This systematic review focuses on the therapeutic impact of baicalin on sepsis complications.
METHODS
This systematic review followed PRISMA guidelines and was reg...
Usamah Sayed, Naji Musa Ali, S. Jyothi et al.· Natural Product Research· 0 citations
Metabolic dysfunction-associated steatotic liver disease, hepatotoxicity, liver fibrosis, and hepatocellular carcinoma are stages of chronic liver injury that occur in the setting of complex interactions of the various factors, including metabolic dysregulation, inflammation, oxidative stress, and cellular senescence....
Amr A. El-Sehrawy, Safa H. Radhie, Mirza R. Baig et al.· Journal of Pharmacology and...· 0 citations
Solute carrier family 7 member 11 (SLC7A11), the functional subunit of the cystine/glutamate antiporter, is described as a major context-dependent regulator of hepatic ferroptosis, which provides protection from ferroptosis caused by different kinds of liver damage.
J. Gupta, Musaab Hamid Farhan, A. Smerat et al.· Tissue & Cell· 0 citations
Myeloproliferative neoplasms (MPN) are shaped by epigenetic rewiring that extends beyond canonical JAK2V617F‐driven signaling. This review argues that context‐dependent chromatin states, not merely genetic lesions, determine disease trajectory, fibrotic transformation, and leukemic progression. We synthesize recent evi...
Amr Ali Mohamed Abdelgawwad El-Sehrawy, M. Al-Khreisat, Aziz Kubaev et al.· Hematological Oncology· 0 citations
Ischemic stroke and subsequent reperfusion injury are major causes of mortality and long-term neurological disability, driven by complex mechanisms of excitotoxicity, oxidative stress, neuroinflammation, endothelial dysfunction, and blood-brain barrier disruption. Increasing evidence indicates that long non-coding RNA...
Amr A. El-Sehrawy, I. Sapaev, O. Nematov et al.· Clinica chimica acta; intern...· 0 citations
The transcriptional coactivators p300 and CREB-binding protein (CBP) integrate chromatin remodeling, enhancer activity, lysine acetylation, immune signaling, and tumor-suppressor control, making them recurrent targets of viral proteins. This narrative review examines p300/CBP at the virus-cancer interface, prioritizing...
A. Atoom, J. Rizaev, D. Polatova et al.· Cancer Treatment and Researc...· 0 citations
Oncolytic virotherapy has evolved from a tumor-selective cytolytic strategy into a programmable immunotherapeutic platform that reshapes the tumor microenvironment (TME). Oncolytic viruses (OVs) selectively infect malignant cells, induce immunogenic cell death, release tumor antigens, and activate innate and adaptive i...
A. Atoom, J. Rizaev, D. Polatova et al.· Cancer Treatment and Researc...· 0 citations
This review aims to examine the emerging roles of OSM in BC, elucidate its multifunctional role in tumor regulation and progression, and ultimately explore therapeutic strategies developed to modulate this cytokine in the context of BC.
Muslem Nuseir, Farrukh Ismatov, A. Abdulqader et al.· IUBMB Life - A Journal of th...· 0 citations
Challenges such as scalable production, cargo heterogeneity, and regulatory considerations remain, but ongoing advances in exosome engineering and patient-derived vesicles are poised to overcome these barriers.
Amr Ali Mohamed Abdelgawwad El-Sehrawy, Hassan Youssef Hussein, O. Nematov et al.· DARU Journal of Pharmaceutic...· 0 citations
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