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Author

Neelanjana Sengupta

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#protein folding Oct 2026

Efficient deduction of encoded local response within a thermodynamically perturbed folded protein.

Externally imposed perturbations can subtly reshape protein structure and mechanics prior to the emergence of global unfolding signatures. Delineating locally sensitive zones, however, can pose immense challenges. Subjecting a small folded protein to isotropic pressure spanning 0.001-10 kbar, we develop a simplified an...

Mandira Dinda, P. Dutta, Manasvini Subramanian et al. · 0 citations
Review Jul 2026

Molecular crowding and amyloidogenic self-assembly: Emergent perspectives from modern computations.

This review emphasizes the context-dependent role of crowding in balancing native protein stability against aggregation propensity, highlighting how heterogeneous intracellular environments govern the emergence of functional assemblies or pathological amyloids.

Sanjana Pandey, Neelanjana Sengupta · 0 citations

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