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Sep 2026

Prognostic Value of Cardiac MRI-derived Diastolic Function for Adverse Cardiovascular Outcomes: Insights from UK Biobank.

Background Although diastolic function markers can help predict adverse outcomes in cardiac disease, the prognostic value of cardiac MRI-derived metrics at a population level remains unclear. Purpose To assess the independent and incremental prognostic value of cardiac MRI-derived diastolic function metrics for adverse...

A. Mahmood, S. Chadalavada, K. Hesse et al. · 0 citations
Open access Aug 2026

Dual inhibition of SGLT 1 and 2 by sotagliflozin alleviates intracellular sodium overload and improves cardiometabolic remodelling in uraemic cardiomyopathy.

AIMS Chronic kidney disease (CKD) is associated with uraemic cardiomyopathy characterised by early metabolic dysfunction. Elevated myocardial intracellular sodium (Naᵢ) has emerged as a driver of cardiometabolic remodelling, however, its role in CKD and therapeutic modulation remains unclear. We investigated whether du...

Megan Young, A. Karlstaedt, Sanushi Dambure et al. · 0 citations

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