Natálie Adamcová

Gemcitabine release kinetics determines the anticancer and immunomodulatory activity of HPMA copolymer nanomedicines.

Gemcitabine (Gem) is an effective anticancer drug used for the treatment of various cancers. Nevertheless, its clinical benefit is limited owing to its very short plasma half-life, rapid enzymatic inactivation, and systemic toxicity. Here, we report the design, synthesis, and comprehensive biological evaluation of four...