Author

Natalia Picheta

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Review Open access Aug 2026

Targeting KRASG12C in non-small cell lung cancer: evidence from randomized clinical trials and future therapeutic strategies

Background The Kirsten rat sarcoma viral oncogene homolog G12C (KRASG12C) mutation is no longer an “elusive” target, having become an important therapeutic target in non-small cell lung cancer (NSCLC). The approvals of sotorasib and adagrasib have significantly altered the second-line treatment algorithm. This systemat...

Julia Piekarz, Natalia Picheta, Jakub Pobideł et al. · Frontiers in Oncology · 0 citations

Review Open access Sep 2026

Refining the TCGA Framework: The Pivotal Role of Targeted Next-Generation Sequencing in Resolving Diagnostic Ambiguities in Endometrial Cancer—Systematic Review

The classification of endometrial cancer based on histological examination often fails to accurately predict treatment outcomes for patients. The Cancer Genome Atlas (TCGA) has proposed a new molecular model that more accurately identifies the tumour subtype, enabling more precise treatment. However, its implementation...

Natalia Gierulska, Julia Orzelska, Katarzyna Lachowska et al. · International Journal of Mol... · 0 citations

Review Open access Aug 2026

Datopotamab deruxtecan in breast cancer treatment: a systematic review of clinical efficacy and safety

Dato-DXd demonstrates robust clinical activity in patients with BC, providing superior disease control with a favorable safety profile compared to conventional chemotherapy, and preclinical data suggest that the induction of ICD may contribute to reshaping a heterogeneous TME.

Julia Piekarz, Natalia Picheta, Jakub Pobideł et al. · Frontiers in Immunology · 0 citations