Open access
Sep 2026
MA-5 attenuates disease-associated transcriptomic aging and pathological microglial states in Gaucher disease
Overall, MA-5 suppresses neuroinflammation and reverses accelerated transcriptomic aging, supporting its potential as a therapeutic strategy for GD and other lysosomal storage disorders, as well as for diseases characterized by mitochondrial dysfunction, chronic inflammation, and pathological accumulation.
Y. Tongu, Tomoko Kasahara, Kohta Nakamura et al.
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