MEK/ERK signaling and Bcl-2 family protein changes in influenza-infected cells with differing sulfatide levels.
Influenza A virus (IAV) exploits host pathways to maximize progeny production. Sulfatide, a sulfated glycosphingolipid on the plasma membrane, has been implicated in enhanced influenza replication; however, the underlying host factors remain unclear. Using sulfatide-low COS7 cells, sulfatide-enriched SulCOS1 cells, and...