Nannan Shan

Mitochondrial dysfunction in sepsis: nutritional strategies for restoring bioenergetic homeostasis

Sepsis is increasingly recognized as a syndrome of maladaptive bioenergetic failure in which mitochondrial dysfunction—rather than being a secondary epiphenomenon—acts as a central driver of immune paralysis, endothelial incoherence, and multiple organ injury. Three interconnected molecular lesions are particularly...