Author

Nan Li

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Review Sep 2026

Temozolomide resistance in glioblastoma: Multidimensional networks, core signaling hubs, and targeted therapeutic strategies.

This review systematically illustrates the regulatory networks governing GBM pathogenesis and TMZ resistance, and dissects signaling cascades of distinct resistance mechanisms and crosstalk between core signaling axes, and identifies key regulatory molecules and druggable targets for each resistance phenotype.

Ying Qin, Yu-Fang Zhao, Bo-Wen Li et al. · Biochimica et biophysica act... · 0 citations

Review Open access Sep 2026

Context-dependent roles of cGAS-STING signaling in glioblastoma: Therapeutic resistance, drug delivery, and heterogeneity-informed translation.

A heterogeneity-informed framework for patient stratification and precision immunotherapy development in GBM is proposed, and major translational challenges are highlighted, including blood-brain barrier penetration, cell-type-specific pathway activation, treatment-induced pathway remodeling, and biomarker selection.

Yu-Zhu Long, Tong-Cui Jiang, Yu Long et al. · Biomedicine & pharmacotherap... · 0 citations