Reduced thrombospondin-1 is associated with altered collagen-rich matrix organization in discoid lateral meniscus
In donor-derived models, THBS1 knockdown in NLM cells reduced area-confluence trajectories, increased migration, and decreased collagen-rich matrix in 4-week spheroids, whereas THBS1 overexpression in DLM cells produced reciprocal changes; aggrecan was not consistently altered.
Shun-Jie Yang, Chen Hou, Hui Wang et al.
· Frontiers in Cell and Develo... · 0 citations