Preprint
Aug 2026
Interpreting Protein Language Model Embeddings via Orthogonal Projection for Protein Fitness Prediction
It is shown that PLM embeddings encode patterns correlated with biochemical properties and quantify their contribution to predicting protein fitness, and this technique is readily transferable to problem settings beyond protein fitness prediction.
Paulo Yanez Sarmiento, Pia Francesca Rissom, Manuel Pfeuffer et al.
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