Open access
Aug 2026
LSm4 biomolecular condensates drive XRN2-mediated RNA decay at DNA double-strand breaks to facilitate repair
Maintenance of genome integrity requires accurate repair of DNA double-strand breaks (DSBs), particularly within transcriptionally active regions. Persistent R-loops at DSBs can impede homologous recombination (HR) repair. While factors that resolve R-loops at DSB sites are known, the mechanisms ensuring timely degrada...
Malak M. Darawshe, Laila A. Bishara, Enas R. Abu-Zhayia et al.
· bioRxiv · 0 citations