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Nabanita Mandal

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#protein folding Open access Oct 2026

FE65 Recognition Rewires the Dynamic Contact Network of the Amyloid Precursor Protein Intracellular Domain

The amyloid precursor protein intracellular domain (AICD) is a short, intrinsically disordered signaling fragment that mediates interactions with adaptor proteins involved in APP trafficking and transcription-associated regulation. Among these partners, FE65 recognizes the conserved YENPTY-containing region of AICD,...

Nabanita Mandal, M. Skepö · 0 citations
Open access Sep 2026

The hearing-essential intracellular domain of PCDH15 reveals a new layer of auditory mechanotransduction

Current models of mechanotransduction in inner-ear hair cells explain how force is transmitted through the extracellular tip link but provide little insight into how force is propagated beneath the plasma membrane. Although the CD2 isoform of PCDH15 has been shown to be essential for hearing in mature mammalian hair ce...

J. Van de Velde, Ruxandra Bighiu, Nabanita Mandal et al. · 0 citations

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