Nabanita Biswas

Understanding the role of IQ motif-containing GTPase-activating protein 1 as a potential disruptor of the essential adhesion module at cell-cell junctions

A key mechanism of stabilization of Cadherin-based cell-cell adhesions is through a mechanically modulated interaction to cortical actin filaments. This interaction is facilitated by a cytoplasmic adhesion module comprising of a complex of β-catenin and α-catenin. Recent evidence shows that under specific conditions th...