Author

Na Yu

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Open access Sep 2026

Transketolase-like 1 potentiates PD-1 blockade in hepatocellular carcinoma by glycolysis to prime dendritic cell lactylation

Hepatocellular carcinoma (HCC) exhibits a suboptimal response to immune checkpoint blockade (ICB) therapy; to overcome this resistance, we aimed to delineate key immune resistance factors via multi-omics analysis, develop strategies to block their immunosuppressive axes, and engineer a targeted nanosystem to enhance im...

Heng-Song Cao, Tian Huang, Yue Chai et al. · Signal Transduction and Targ... · 0 citations

Open access Aug 2026

Bio-Engineered Fungal-MOF Nanoplatform Synergizes Macrophage Polarization and Checkpoint Blockade for Potent Melanoma Immunotherapy.

Through this orchestrated modulation, MOF-808-Ro-G/N effectively remodels the TME into an immunologically "hot" niche, promoting robust cytotoxic T lymphocyte infiltration and achieving substantial tumor growth suppression.

Xiaolong Li, Jueshuo Guo, Ting-Ting Meng et al. · Advanced Healthcare Material... · 0 citations