Open access
Oct 2026
Gut microbiota-derived 7-KDCA protects against diabetic sarcopenia by interrupting the NLRP1-ferroptosis crosstalk in myotubes
Type 2 diabetes mellitus (T2DM) accompanied by sarcopenia is an emerging clinical challenge in aging populations, yet the treatment options remain scarce. Recent advances in metabolomics have revealed that gut microbial bile acids function as essential players in muscle mass and function. The aim of the present stu...
Qing-Bo Lu, Chen-Yang Zhao, Le Yang et al.
· Cell Death Discovery · 0 citations