Author

Na Cui

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Open access Aug 2026

Restricted TCR Diversity and Expansion of CD177+CD8+ and TLR4+CD4+T Cell Subsets in Septic Shock‐Associated Immunosuppression: A Single‐Cell Multi‐Omics Study

Sepsis‐induced immunosuppression contributes to poor outcomes in sepsis patients, yet the mechanisms underlying T cell dysfunction remain incompletely understood. We integrated single‐cell RNA sequencing (scRNA‐seq), paired single‐cell T cell receptor sequencing (scTCR‐seq), bulk RNA sequencing (RNA‐seq), and flow cyto...

Ya-Wen Xie, Xun-Yao Wu, Guoyu Zhao et al. · MedComm · 0 citations

Open access Aug 2026

Prediction of severe sepsis-associated acute kidney injury incorporating immune-inflammatory profiles: development and validation of a machine learning model in a multicenter prospective cohort study

Introduction Severe sepsis-associated acute kidney injury (SA-AKI) is a prevalent and life-threatening complication in critically ill patients, leading to increased mortality and a heightened risk of chronic kidney dysfunction. Current prediction models for severe SA-AKI have largely overlooked the inclusion of immune...

Xiaoxia Guo, Fei Li, Chang Xu et al. · Frontiers in Immunology · 0 citations