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Author

N. V. Nikiforova

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Open access Jul 2026

Tissue specificity and age-related dynamics of CAG promoter activity in rAAV-mediated gene therapy

The CAG promoter is poorly suited for transgene expression in the lung and brain cells due to promoter silencing and is suboptimal for expression in the liver cells because of relatively low activity; these findings should be taken into account in the development of gene therapy products.

R. L. Anisimov, N. V. Nikiforova, E. S. Ivanov et al. · 0 citations

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